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FLASH GENE
Symbol PLAC8 contributors: np/ - updated : 05-02-2005
HGNC name placenta-specific 8
HGNC id 19254
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmyelocyte Homo sapiens
cell lineage highly expressed in myeloid cells )
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • putative signal peptides
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • involved in placenta development and fetus maternal interface
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • negative MYC target
  • interaction with and activation of AKT1 and MDM2, and down-regulates TP53
  • PLSCR1 interacts with the same cysteine-rich domain of PLAC8 as do AKT1 and MDM2, whereas the PLAC8-interacting domain of PLSCR1 centers around, but does not require, a previously identified palmitoylation signal
  • cell & other
    REGULATION
    Other regulated by PLSCR1 (physiologic regulator of PLAC8, with a functional interdependence between PLAC8 and PLSCR1)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS