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FLASH GENE
Symbol PIGS contributors: np/mct - updated : 25-10-2018
HGNC name phosphatidylinositol glycan anchor biosynthesis, class S
HGNC id 14937
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to S.cerevisiae gpi17p
Homologene
FAMILY
  • PIGS family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • required for attachment of GPI anchor to proteins, transamidase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with PIGK, PIGI, GAA1
  • PIGS and PIGT are components of the GPI transamidase complex and are essential for the formation of the carbonyl intermediates necessary when the transamidase complex transfers the GPI group to the protein
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PIGT, PIGU, and GPAA1 may form a core complex associated by PIGS, and these four subunits may stabilize PIGK, triggering GPI anchoring reactions
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GPIBD18
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS