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FLASH GENE
Symbol NEUROD6 contributors: shn - updated : 11-05-2012
HGNC name neuronal differentiation 6
HGNC id 13804
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   specific Homo sapiens
Visualeyeretina    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Visualamacrine cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
Text central nervous system (
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • poly Glu
  • nuclear localization signal (NLS)
  • DNA binding basic domain
  • helix-loop-helix motif
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to Neurod6, Mus musculus
    ortholog to Neurod6, Rattus norvegicus
    ortholog to NEUROD6, Pan troglodytes
    Homologene
    FAMILY NEUROD family of basic helix-loop-helix transcription factors
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • Has the ability to trigger neuronal differentiation of PC12 cells in the absence of neurotrophic factor, plays an important role in neurite outgrowth and has the capacity to regenerate neurite outgrowth in the absence of nerve growth factor (
  • Modulates a wide spectrum of genes with diverse functions, many of them being key downstream regulators of the NGF pathway, and critical to neuritogenesis, such as microtubules, microtubule-associated proteins and intermediate filaments (
  • Neuritogenesis and regeneration (
  • Links neuronal differentiation to survival via the network of molecular chaperones and endows the cells with increased stress tolerance (
  • Stimulates maximal mitochondrial mass at the lamellipodia stage, thus preceding axonal growth, triggers remodelling of the actin and microtubule networks in conjunction with increased expression of the motor protein KIF5B, thus promoting mitochondrial movement in developing neurites with accumulation in growth cones (
  • Plays an integrative role in co-ordinating increase in mitochondrial mass with cytoskeletal remodelling and may be a co-regulator of neuronal differentiation and energy metabolism (
  • A regulator of ROS homoeostasis, resulting in enhanced tolerance to oxidative stress (
  • Regulates with AT-rich-sequence-binding protein 2 a postmitotic cell fate choice between wide/medium-field GABAergic amacrine cells and narrow-field glycinergic amacrine cells subtypes (
  • CELLULAR PROCESS nucleotide, transcription, initiation
    PHYSIOLOGICAL PROCESS development , nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • directly regulates LPPR4 expression and the NEUROD6 -LPPR4 cascade plays an important role in neurite outgrowth
  • upon stress, NEUROD6 promotes colocalization of BCL2L2 with mitochondria and endoplasmic reticulum
  • NEUROD4 and NEUROD6 are factors that are closely related to NEUROD1 and NEUROD2
  • cell & other
    REGULATION
    activated by dimerization with another BHLH protein
    induced by auto-transactivation (NEUROD6)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS