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FLASH GENE
Symbol NAPG contributors: mct - updated : 22-10-2012
HGNC name N-ethylmaleimide-sensitive factor attachment protein, gamma
HGNC id 7642
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticplatelet
Skin/Tegumentmelanocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Napg
homolog to Drosophila 8ggi.Snap
homolog to C.elegans Y59A8B.8
homolog to rattus LOC307382
Homologene
FAMILY SNAP family
CATEGORY structural protein
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • required for the membrane fusion and vesicular transport between the endoplasmic reticulum and the Golgi apparatus
  • meditates platelet exocytosis and controls the membrane fusion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to NSF
  • interacting with GAF1
  • RAB11FIP5 participates in endosomal recycling through the interaction with both NAPG, a member of the soluble NSF attachment protein family, and a small GTPase, RAB11A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to bipolar disorder
    Variant & Polymorphism SNP
  • rs2290279, rs495484 and rs510110, show a nominal, statistically significant association with bipolar disorder
  • Candidate gene
  • candidate for susceptibility to bipolar disorder
  • Marker
    Therapy target
    ANIMAL & CELL MODELS