basic FUNCTION
| involved in the synthesis of alpha-(+)-lipoic acid |
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may be involved in the sulfur insertion chemistry in lipoate biosynthesis |
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involved in the endogenous synthesis of lipoic acid, a potent mitochondrial antioxidant |
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in mitochondria, lipoic acid synthase produces alpha-lipoic acid, an antioxidant and an essential cofactor in alpha-ketoacid dehydrogenase complexes, which participate in glucose oxidation and ATP generation |
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lipoic acid is synthesized within the mitochondria by the enzyme, Lipoic acid synthase (LIAS) |
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LIPT2 and LIAS are involved in the lipoylation of GCS H protein |