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FLASH GENE
Symbol KREMEN1 contributors: mct - updated : 05-10-2010
HGNC name kringle containing transmembrane protein 1
HGNC id 17550
EXPRESSION
Rna function mRNA expression is low in the early stages, but gradually and continuously increases with developmental progression and differentiation
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinepancreas    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • a kringle domain
  • a WSC, a CUB domain
  • six glycosylation sites in the extracellular region
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to murine Kremen
    homolog to rattus Kremen
    homolog to Xenopus Xl.12084
    Homologene
    FAMILY
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • DKK receptor, cooperating with DKK1 to block WNT, beta catenin signaling pathway
  • playing a role for in proper development of thymic epithelium
  • not universally required for DKK1 function
  • inducing exocytosis, cell cell interaction
  • functions as the gatekeeper of Wnt signalling in development and pathology )
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , cell to cell transport , exocytosis transport , electron transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of a ternary complex with DKK1 and the lipoprotein related protein - (LRP6)
  • components of a membrane complex modulating canonical WNT signaling through LRP6
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to LRP6, KREMEN2
  • with KREMEN2, identified to be the high-affinity receptors for Dickkopf (Dkk), the inhibitor of Wnt/beta-catenin signalling
  • functional interaction of Kremen proteins with DKK1 as negative regulators of Wnt/beta-catenin signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to schizophrenia in the Japanese
  • Variant & Polymorphism other
  • a common variant in the promoter region of KREMEN1 might modulate the risk of schizophrenia in the Japanese
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Krm double mutants show enhanced Wnt signaling accompanied by ectopic postaxial forelimb digits and expanded apical ectodermal ridges