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FLASH GENE
Symbol KCNE4 contributors: mct - updated : 08-06-2011
HGNC name potassium voltage-gated channel, Isk-related family, member 4
HGNC id 6244
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   predominantly Homo sapiens
Nervousbrain   predominantly Homo sapiens
Reproductivefemale systemovary   
 male systemtestis  predominantly Homo sapiens
 male systemprostate   
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text moderately in placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a glycosylation site
  • a transmembrane domain
  • a cytoplasmic domain of KCNE4 that is necessary for its inhibition of KCNQ1
  • a tetraleucine motif in the juxtamembrane region of the C terminus , interacting with KCNQ1
  • mono polymer heteromer , complex
    HOMOLOGY
    interspecies ortholog to murine Kcne4
    intraspecies homolog to KCNE1
    Homologene
    FAMILY potassium channel E family
    CATEGORY regulatory , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • ancillary protein modulating the gating kinetics and enhance stability of the multimeric complex
  • inhibiting potassium current by inhibiting KCNQ1 activation
  • may act as a subunit of KCNJ2 channel to modulate the potassium channel function
  • functions as an inhibitory KCNA3 partner in leukocytes
  • KCNE4 association might play a crucial role in controlling immunological responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism
    signaling
    a component
  • potassium channel alpha subunit, like KCNQ1
  • directly associates with KCNQ1, and can co-associate together with KCNE1 in the same KCNQ1 complex to form a 'triple subunit' complex (KCNE1-KCNQ1-KCNE4)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may coassemble with KCNQ subunits
  • has a dramatic inhibitory effect on KCNQ1 that differs substantially from the activating effects of KCNE1 and KCNE3
  • associates with KCNA3 in the ER and decreases the number of KCNA3 channels at the cell surface, which diminishes cell excitability
  • modulate KCND current activation, inactivation and recovery from inactivation, in a KCNIP2-dependent manner
  • can biochemically interact with CALM1 and this interaction is Ca(2+)-dependent and requires a tetraleucine motif in the juxtamembrane region of the KCNE4 C terminus
  • interaction between KCNE4 and CALM1 could be involved in the modulation of KCNQ1 by KCNE4
  • CALM1-KCNE4 interactions might constitute part of a feedback loop for regulating intracellular Ca2+
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS