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FLASH GENE
Symbol ITGA8 contributors: mct - updated : 11-03-2016
HGNC name integrin, alpha 8
HGNC id 6144
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel     Homo sapiens
Reproductivemale systemprostate   
Respiratorylungalveoli   
Urinarykidney   highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularsmoothvessel   Homo sapiens
Muscularstriatumcardiacmyocardium 
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell Homo sapiens
Muscularmyoblast
Urinarymesangial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text developing kidney
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extracellular heavy chain with seven FG-GAP repeats
  • 13 N-glycosylation sites
  • three calcium binding sites, a cell attachment site, linked by a disulfide bond to a light chain with an extracellular domain with two N-glycosylation sites
  • a transmembrane and a cytoplasmic domain
  • conjugated GlycoP
    mono polymer heteromer , dimer
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to murine Itga8
    homolog to rattus Rn.69726
    homolog to Drosophila scb
    homolog to C.elegans F54F2.1
    Homologene
    FAMILY integrin alpha chain family
    CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in cell-cell adhesion and cell- matrix adhesion
  • implicated in cardiac fibrosis
  • the influence of ITGA8 on the expression of matrix components was not uniform and celltype dependent, and seems unlikely to exert overall profibrotic effects in renal cells
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development
    text kidney morphogenesis
    PATHWAY
    metabolism
    signaling
    a component ITGA8 and ITGB1
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding to fibronectin (FN1), vitronectin, tenascin (by their RGD sites)
    cell & other
    REGULATION
    induced by in response to pro-hypertrophic and pro-fibrotic agent angiotensin II
    ASSOCIATED DISORDERS
    corresponding disease(s) BRA1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    associated with increased cardiac interstitial fibrosis
    tumoral     --low  
    by aberrant promoter methylation in ovarian cancers (Cai 2007)
    constitutional germinal mutation      
    in isolated Congenital anomalies of the kidney and urinary tract (CAKUT)
    Susceptibility
  • to hypertrophic cardiomyopathy
  • to modification of the progression of renal failure in autosomal-dominant polycystic kidney disease (ADPK
  • Variant & Polymorphism other
  • modifier gene of MYBPC3, in hypertrophic cardiomyopathy
  • polymorphism of the ITGA8 promoter modifies the progression of renal failure in ADPKD
  • Candidate gene
    Marker
  • ITGA2B, ITGA8, GIT1, and SHC1 were identified as independent prognostic factors of overall survival of clear cell renal cell carcinoma
  • Therapy target
    ANIMAL & CELL MODELS
  • mice deficient for ITGA8 have structural alterations in glomeruli but not in renal arteries