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FLASH GENE
Symbol IL18RAP contributors: mct - updated : 06-06-2008
HGNC name interleukin 18 receptor accessory protein
HGNC id 5989
EXPRESSION
Rna function testis
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen    
 thymus    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Lymphoid/Immunemacrophage
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 14-amino acid signal peptide
  • a 342-amino acid extracellular (Ig superfamily-like) segment
  • three Ig like domains
  • three glycosylation potential sites
  • single transmembrane region
  • a 222-amino acid cytoplasmic domain
    • mono polymer heteromer , dimer
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to murine Il18rap
    Homologene
    FAMILY
  • interleukin-1 receptor (IL-1R) family
    • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • required for induction of NFkappaB activity and for activation of c-Jun N-terminal kinase
  • pleiotropic cytokine involved in the regulation of both innate and adaptive immunity and playing a key role in the autoimmune, inflammatory and infectious diseases
  • essential for IL-18 signal transduction and ligand binding affinity to IL-18Ralpha receptor chain
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text Th1 immune response
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • heterodimerizing with IL18R1
  • component of IL18 receptor
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by IFN-alpha,IL-12
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Crohn's disease and ulcerative colitis
    Variant & Polymorphism SNP increasing the risk of Crohn's disease and ulcerative colitis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS