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FLASH GENE
Symbol HCN3 contributors: mct/npt - updated : 18-03-2019
HGNC name hyperpolarization activated cyclic nucleotide-gated potassium channel 3
HGNC id 19183
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Nervousbrainhindbraincerebellum   Rattus norvegicus
cells
SystemCellPubmedSpeciesStageRna symbol
NervousPurkinje cell Rattus norvegicus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • cytoplasmic domain with a domain involved in subunit assembly
  • two transmembrane domains (S1,S2)
  • two transmembrane domains (S3, voltage- sensing S4)
  • a transmembrane domains (S5)
  • a glycosylation site
  • a membrane pore forming domain H5
  • a transmembrane domain S6
  • a cytoplasmic domain with an cAMP binding domain and a Pro-rich domain
  • conjugated GlycoP , Other
    mono polymer homomer , heteromer , tetramer
    HOMOLOGY
    interspecies ortholog to murine Hcn3
    homolog to rattus Hcn3
    Homologene
    FAMILY
  • potassium channel HCN family
  • superfamily of voltage-gated pore loop channels
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • having a hyperpolarization-activated cation (potassium) channel activity)
  • inward current activated by hyperpolarization from the resting potential and an important modulator of action potential firing frequency in many excitable cells (Momin 2008)
  • plays a key role in the control of cardiac and neuronal rhythmicity ("pacemaker current"), and contributes to several other neuronal processes, including determination of resting membrane potential, dendritic integration and synaptic transmission (Wahl-Schott 2009)
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • cAMP
  • potassium K+
  • protein
    cell & other
    REGULATION
    activated by hyperpolarization (voltage)
    cAMP
    inhibited by rapidly and reversibly by extracellular cesium and slowly and irreversibly by extracellular applied ZD7288 (Stieber 2005)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS