basic FUNCTION
| plays a critical role in mitosis, particularly in centrosome duplication to form a bipolar spindle during prometaphase and in cytokinesis where replicating cells split to form two daughter cells at telophase |
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apoptosis initiated via the mitochondria/cytochrome c pathway |
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functioning as a cofactor for survivin, and serving as a link between the cellular apoptosis machinery and a viral pathogen involved in hepatocellular carcinogenesis |
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critical target of viral HBx for promoting genetic instability through formation of defective spindles and subsequent aberrant chromosome segregation |
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one of its functions is its involvement in cell proliferation |
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able to promote the proliferation of cells |
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able to enhance migration of breast cancer cells |
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promotes the proliferation and migration of breast cancer cells |
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LAMTOR5-activated the PTEN/PI3K/AKT signaling by inducing DNA methylation of PTEN, which subsequently boosted S100A4 expression |
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LAMTOR4, LAMTOR5 are two additional Ragulator components that are required for MTOR activation by amino acids |
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guanine nucleotide exchange factor (GEF) for the RAG GTPases |
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up-regulates SKP2 via activating E2F1 to promote proliferation of breast cancer cells |
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is an oncoprotein playing crucial roles in the development of cancer, involving glucose metabolism reprogramming |