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FLASH GENE
Symbol GABRP contributors: - updated : 07-06-2006
HGNC name gamma-aminobutyric acid (GABA) A receptor, pi
HGNC id 4089
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuterus   
 female systemovary   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY receptor membrane
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • involved in alteration of chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system
  • having a function related to tissue contractility
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component binding of this pi subunit with other gaba(a) receptor subunits
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding with other gaba(a) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to schizophrenia
    Variant & Polymorphism SNP increasing the risk of schizophrenia
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS