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FLASH GENE
Symbol AP2B1 contributors: - updated : 20-05-2006
HGNC name adaptor-related protein complex 2, beta 1 subunit
HGNC id 563
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
Reproductivemale systemtestis  highly
Respiratoryrespiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two globular adaptin domains interconnected by a variable and potentially flexible stalk domain
  • mono polymer heteromer , tetramer
    HOMOLOGY
    Homologene
    FAMILY adaptor complexes large subunits complex
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text cytoplasmic face of clathrin coated vesicles
    basic FUNCTION
  • potentially mediating rapid internalization
  • playing a major role in clathrin coat formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of assembly protein complex AP-2, clathrin coat assembly complex linking clathrin to receptors in coated pits and vesicles
  • heterotetramer composed of two large chains (alpha and beta),a medium chain (AP50) and a small chain (AP17)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with both cargo and clathrin
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS