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FLASH GENE
Symbol ZFP36L1 contributors: mct/ - updated : 05-03-2011
HGNC name zinc finger protein 36, C3H type-like 1
HGNC id 1107
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
 thyroid   highly
Hearing/Equilibriumear   highly
Respiratoryrespiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • transactivation domains
  • a distinguishing putative zinc finger domain with a repeating cys-his motif (two C3H1-type zinc fingers)
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to murine Zfp36l1
    homolog to C.elegans f38b7.1b
    intraspecies homolog to tristetraprolin
    Homologene
    FAMILY
  • CCCH tandem zinc finger proteins (TTP family)
  • TIS11 family of early response genes
  • tristetraprolin family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    text shuttle between the nucleus and cytoplasm
    basic FUNCTION
  • specifying a putative nuclear transcription factor, functioning in regulating the response to growth factors
  • acting as as an essential regulator of ARE-dependent mRNA decay
  • might also be an important player during myogenic differentiation and regeneration, and an important regulator of myogenesis
  • may be an important regulator of VEGF expression
  • modulator of vascular endothelium growth factor (VEGF) mRNA stability, and important role of ZFP36L1 in wound healing
  • role for ZFP36L1 and ZFP36L2 during thymocyte development and in the prevention of malignant transformation
  • negatively regulates erythroid differentiation by directly binding the 3prime untranslated region of STAT5B encoding mRNA
  • effective in repressing a broad spectrum of target mRNAs bearing structurally distinct AREs in tumor cells
  • enhances vascular endothelial growth factor (VEGF) mRNA decay through its interaction with AU-rich elements within VEGF 3prime-untranslated region
  • involved in AU-rich-dependent regulation of mRNA stability/degradation
  • ZFP36L1-mediated mechanism is used by endothelial cells under hypoxia for controlling DLL4 mRNA levels
  • new function in mammalian cell mRNA 3prime-end maturation
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text required for apoptosis in Ramos B cells induced through Ca2+ signaling and as a target for IL-4
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • negative regulator of VEGFA gene activity during development
  • interact with AU-rich elements in the 3prime untranslated region of mRNA, which leads to mRNA degradation and translational repression
  • Dll4 is a physiological target of ZFP36L1 (binds to endogenous DLL4 mRNA, and represses mRNA expression without affecting its stability)
  • cell & other
    REGULATION
    induced by various agonists such as the phorbol ester.TPA and the polypetide mitogen EGF
    calcium ionophore
    ACTH
    a broad variety of growth factors and cytokines, and by scratch wounding
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    R9-ZFP36L1 may potentially control invasive behavior of aggressive tumors (R9-ZFP36L1 fusion protein may represent a novel antiangiogenic and antitumoral agent)
    ANIMAL & CELL MODELS