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FLASH GENE
Symbol AK8 contributors: mct - updated : 25-05-2021
HGNC name adenylate kinase 8
HGNC id 16715
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Reproductivemale systemprostate   
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DEAD/H box (Asp - Glu - Ala - Asp/His)
  • C terminal RNA helicase domain
  • two complete and active AK domains within its polypeptide chain, a feature that has previously been shown for AK5
  • HOMOLOGY
    Homologene
    FAMILY
  • DEAD box helicase family
  • DDX31/DBP7 subfamily
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text
  • cytosolic localization
  • AK8, is present in a third flagellar compartment, the axoneme of sperm tail
  • basic FUNCTION
  • both AK7 and AK8 showed highest affinity for AMP with ATP as the phosphate donor, and are more efficient in AMP phosphorylation as compared with the major cytosolic isoform AK1 (
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
  • ATP
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS