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FLASH GENE
Symbol CTDP1 contributors: - updated : 04-05-2007
HGNC name CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
HGNC id 2498
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Endocrinepancreas    
Lymphoid/Immunespleen    
Visualeyeanterior segment   
 eyelens   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelial    
cells
SystemCellPubmedSpeciesStageRna symbol
Endocrineislet cell (alpha,beta...)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text posterior rhombomere
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C terminal domain phosphatase
  • one BRCT domain
  • one FCP1 homology domain
  • conjugated PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to murine Ctdp1
    homolog to dog LOC476158
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • an essential component of the eukaryotic transcription machinery
  • stimulating transcript elongation by RNAP II
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • may be a component of a RNA polymerase II holoenzyme complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein GTF2F1 (when phosphorylated)
    cell & other
    REGULATION
    activated by GTF2F1
    Other regulated by phosphorylation
    ASSOCIATED DISORDERS
    corresponding disease(s) CCFDN
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS