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FLASH GENE
Symbol CNNM3 contributors: mct - updated : 28-12-2016
HGNC name cyclin and CBS domain divalent metal cation transport mediator 3
HGNC id 104
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Urinarykidneytubuleconvoluted tubuleproximal tubule  Other species
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two conserved CBS forming a stable globular domain
  • HOMOLOGY
    interspecies homolog to murine Cnnm3
    Homologene
    FAMILY
  • ACDP family
  • CATEGORY protooncogene , signaling cytokine
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • Mg(2+) transporter that is itself pro-oncogenic
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PTP4A2 regulates intracellular magnesium levels by forming a functional heterodimer with the magnesium transporter CNNM3
  • PTP4A2 modulates intracellular Mg(2+) levels and sustains cancer phenotypes by binding to the Mg(2+) transporter CNNM3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS