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FLASH GENE
Symbol CLGN contributors: mct - updated : 19-10-2011
HGNC name calmegin
HGNC id 2060
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   moderately
Endocrinepancreas   moderately
Nervousbrain   moderately
Reproductivemale systemtestis  highly Homo sapiens
Respiratorylung   moderately
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophilic Hydrophobic
STRUCTURE
motifs/domains
  • an N-terminal hydrophobic signal peptide
  • two sets of internal repetitive sequences
  • a hydrophilic C terminus with a transmembrane domain and an ER retention signal
  • HOMOLOGY
    interspecies ortholog to murine Clgn
    homolog to rattus Rn.52725
    homolog to Drosophila Cnx99A
    homolog to C.elegans cnx-1
    intraspecies homolog to testis-specific homologs of CANX
    Homologene
    FAMILY calreticulin family
    CATEGORY chaperone/stress , storage
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    intracellular,nuclear envelope
    text
  • type I membrane protein
  • CLGN is membrane-anchored whereas CALR3 is soluble
  • basic FUNCTION
  • testis-specific endoplasmic reticulum chaperone protein playing a role in spermatogeneisis and infertility
  • involved in calcium ion storage
  • having defective zona-binding ability
  • CANX-like lectin chaperone during spermatogenesis and required for the assembly of ADAM (a disintegrin and metalloproteinase) sperm fertilizing proteins ADAM1/ADAM2
  • required for ADAM1A/ADAM2 dimerization and subsequent maturation of ADAM3A
  • testis-specific calreticulin homologs CLGN and CALR3 have distinct but cooperative roles in the maturation of ADAM3A during spermatogenesis and subsequent sperm fertilizing ability
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a tissue-specific chaperone complex with the calnexin homologue calmegin (CLGN)
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • binding fertilin beta (ADAM2)
  • its expression is regulated by HDAC and CpG methyltransferase in a coordinative way
  • cell & other
    REGULATION
    Other transcriptionally regulated by histone deacetylase (HDAC) and CpG methyltransferase
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    reproductioncontraception 
    manipulation of the testis-specific CLGN/CALR3 ER quality control system could be exploited to develop novel therapeutic approaches for contraception
    reproductionfertility 
    manipulation of the testis-specific CLGN/CALR3 ER quality control system could be exploited to develop novel therapeutic approaches for treatment of male infertility
    ANIMAL & CELL MODELS