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FLASH GENE
Symbol CMTM7 contributors: mct - updated : 13-09-2012
HGNC name CKLF-like MARVEL transmembrane domain containing 7
HGNC id 19178
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
four transmembrane domains
HOMOLOGY
interspecies ortholog to murine Cklfsf7
Homologene
FAMILY chemokine-like factor gene superfamily
CATEGORY signaling
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
basic FUNCTION
  • tetra-spanning membrane protein, functioning to link surface IgM and BLNK in the plasma membrane, to recruit BLNK to the vicinity of SYK, and to initiate the BLNK-mediated signal transduction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bound to BLNK in a membrane fraction, and their association was augmented after surface IgM ligation
  • cell & other
    REGULATION
    Phosphorylated by SYK and binds various signaling intermediates, leading to cellular events including MAP-kinase activation, culminating in cellular activation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS