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FLASH GENE
Symbol CHKA contributors: mct - updated : 20-10-2012
HGNC name choline kinase alpha
HGNC id 1937
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Reproductivefemale systembreast   
 male systemprostate   
Respiratorylung    
cell lineage
cell lines breast cancer, colon cancer, lung cancer, prostate cancer
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , tetramer
HOMOLOGY
interspecies homolog to murine Chk
homolog to rattus Chka
Homologene
FAMILY
  • choline/ethanolamine kinases family
  • ChoK family of proteins
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalysing the phosphorylation of choline and ethanolamine by ATP
  • may be involved in human carcinogenesis
  • having a regulatory role in phosphatidylcholine pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SRC-dependent link between CHKA and EGFR, which contributes to the regulation of cell proliferation and tumorigenesis
  • cell & other
    REGULATION
    activated by Ras proteins through Ral-GDS and PI3K
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer, colon cancer, lung cancer, prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • disruption of murine Chka leads to embryonic lethality