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FLASH GENE
Symbol NPRL3 contributors: mct/npt - updated : 28-06-2017
HGNC name NPR3 like, GATOR1 complex subunit
HGNC id 14124
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Lymphoid/Immunelymph node   highly
 spleen   highly
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to the yeast gene Npr3
intraspecies paralog to NPRL2
Homologene
FAMILY
  • UPF0171 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    text nuclear and cytosolic distribution, and can localize to PML nuclear bodies (Lunardi 2009)
    basic FUNCTION
  • inhibits cell proliferation in a dose-dependent manner
  • is required for normal development of the cardiovascular system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • DEPDC5, NPRL2 and NPRL3 are components of Gap Activity TOward Rags 1 (GATOR1), a complex involved in the inhibition of the mTOR complex 1 (MTOR)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with human TP73 (can modulate differentially the specific activities of selected TP73 isoforms) (Lunardi 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FFEVF3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    inhibit cell proliferation (Lunardi 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • is a candidate gene for harbouring mutations in individuals with developmental abnormalities of the cardiovascular system
  • Marker
    Therapy target
    ANIMAL & CELL MODELS