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FLASH GENE
Symbol ELK3 contributors: - updated : 20-05-2006
HGNC name ELK3, ETS-domain protein (SRF accessory protein 2)
HGNC id 3325
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrinepancreas    
Lymphoid/Immunelymph node   highly
Reproductivefemale systemuterus  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
cell lineage cell maturation
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • transcription regulator containing the ETS DNA-binding motif (Box A)
  • a domain (Box B) mediating the interaction with serum response factor (SRF)
  • a domain (Box C) regulating transcriptional activation
  • HOMOLOGY
    interspecies homolog to murine Net (Erp)
    intraspecies homolog to ets protooncogene 3
    Homologene
    FAMILY
  • divergent member of the winged helix-turn-helix superfamily
  • ETS family
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • may be a negative regulator of transcription, but can activate transcription when coexpressed with RAS, SRC, or MOS
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with NOS2A (important mediator of its expression)
  • cell & other
    REGULATION
    activated by RAS
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS