basic FUNCTION
| clearance of chylomicrons, remnants and beta-VLDL from the plasma |
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modulates glutamate receptor function and synaptic plasticity by regulating apoE receptor recycling in neurons, with APOE3 stimulating and APOE4 inhibiting this process |
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in the nervous system, functions as a major carrier and distributor of cholesterol and other lipids, which are essential components of neuronal membranes and myelin sheaths |
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is required for maintenance of the dentate gyrus neural progenitor pool |
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APOE-induced intracellular APP degradation is mediated by the cholesterol efflux function of APOE, which lowers cellular cholesterol levels and subsequently facilitates the intracellular trafficking of APP to lysosomes for degradation |
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plays an important role in lipoprotein metabolism |
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role of APOE and COMT genes in prospective and retrospective memory traits |
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putative functional role of APOE in modulating myelin-related processes in the brain |
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major cholesterol carrier that supports lipid transport and injury repair in the brain |
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influences soluble APP metabolism not through direct binding to soluble APP in solution but through its actions with other interacting receptors/transporters and cell surfaces |
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APOE4 allele drives atrophy to the medial-temporal lobe region in AD |
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has an intrinsic role in pericyte mobility, which is vital in maintaining cerebrovascular function |
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role for APOE in lipid accumulation and adipogenic differentiation in adipose tissue |
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APOE is a critical determinants of brain phospholipid homeostasis and the APOE4 isoform is dysfunctional in this process |
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is an essential anti-atherosclerotic glycoprotein involved in lipid metabolism |
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impaired autophagy may play a role in mediating the pathological effects of APOE4 in AD |
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negative role of the APOE4 allele for cognitive performance in late life, while beneficial effects on cognition have been shown in young age |