Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

CAPZB

contributors: mct - updated : 20-11-2018

HGNC name	capping protein (actin filament) muscle Z-line, beta
HGNC id	1491

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx       highly Reproductive female system breast mammary gland   highly Respiratory respiratory tract larynx     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

beta subunit of the barbed end actin binding protein

mono polymer

heteromer , dimer

HOMOLOGY

interspecies

homolog to murine Cappb1

Homologene

FAMILY

f-actin capping protein beta subunit family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton

basic FUNCTION	involved in the regulation of growth of the actin filament by capping the barbed end of growing actin filaments
	CAPZB and PDE8B have been linked to TSH levels
	is an actin-capping protein that caps the growing end of F-actin and modulates the cytoskeleton and tethers actin filaments to the Z-line of the sarcomere in muscles
	actin filament length regulators CFL1, CAPZB and DIAPH1 regulate mitotic cortex thickness and both increasing and decreasing thickness decreases tension in mitosis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

heterodimer of an alpha and a beta subunit

INTERACTION

DNA

RNA

small molecule

protein

QKI promotes inclusion of CAPZB exon 9 in opposition to repression by polypyrimidine tract-binding protein (PTB)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral         silencing of CAPZB inhibited the growth, invasion and migration of epithelioid sarcoma

Susceptibility

to TSH variation

Variant & Polymorphism SNP	rs10917469, located near CAPZB is assocaiated to TSH variation

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     may be a potential therapeutic target in epithelioid sarcoma

ANIMAL & CELL MODELS