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FLASH GENE
Symbol CAPZB contributors: mct - updated : 20-11-2018
HGNC name capping protein (actin filament) muscle Z-line, beta
HGNC id 1491
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Reproductivefemale systembreastmammary gland highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • beta subunit of the barbed end actin binding protein
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Cappb1
    Homologene
    FAMILY
  • f-actin capping protein beta subunit family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • involved in the regulation of growth of the actin filament by capping the barbed end of growing actin filaments
  • CAPZB and PDE8B have been linked to TSH levels
  • is an actin-capping protein that caps the growing end of F-actin and modulates the cytoskeleton and tethers actin filaments to the Z-line of the sarcomere in muscles
  • actin filament length regulators CFL1, CAPZB and DIAPH1 regulate mitotic cortex thickness and both increasing and decreasing thickness decreases tension in mitosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer of an alpha and a beta subunit
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • QKI promotes inclusion of CAPZB exon 9 in opposition to repression by polypyrimidine tract-binding protein (PTB)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    silencing of CAPZB inhibited the growth, invasion and migration of epithelioid sarcoma
    Susceptibility to TSH variation
    Variant & Polymorphism SNP
  • rs10917469, located near CAPZB is assocaiated to TSH variation
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may be a potential therapeutic target in epithelioid sarcoma
    ANIMAL & CELL MODELS