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FLASH GENE
Symbol ASB11 contributors: mct - updated : 10-06-2020
HGNC name ankyrin repeat and SOCS box-containing 11
HGNC id 17186
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six ankyrin repeats
  • one SOCS box domain
    • HOMOLOGY
    interspecies ortholog to murine Asb11 (85 pc)
    Homologene
    FAMILY
  • ankyrin repeat
  • SOCS box-containing (ASB) family
    • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in couplage of suppressor of cytokine signaling (SOCS) protein and their partners with elongin B and C
  • is likely a principal regulator of embryonic as well as adult regenerative myogenesis
  • ASB11 is a novel endoplasmic reticulum-associated ubiquitin ligase with the ability to interact and promote the ubiquitination of RPN1, an integral protein of the oligosaccharyltransferase (OST) glycosylation complex
    • CELLULAR PROCESS protein, post translation, targeting
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    intracellular signaling cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • JAK kinases
  • activated cytokine receptors
  • elonguin B/C complex
  • expression of ASB11 can increase RPN1 protein turnover (24337577)
  • CUL5-ASB11 is the E3 ligase targeting BIK for ubiquitination and degradation
  • different cellular stresses regulate BIK ubiquitination by ASB11 in opposing directions, which determines whether or not cells survive
    • cell & other
    REGULATION
    induced by cytokines
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS