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FLASH GENE
Symbol CD97 contributors: mct - updated : 20-10-2012
HGNC name CD97 molecule
HGNC id 1711
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   moderately
 stomach   highly
Lymphoid/Immunespleen   highly
 thymus   highly
Nervousbrain   moderately
Reproductivefemale systemuteruscervix highly
 male systemprostate  moderately
Respiratorylung   moderately
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularsmooth   
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Lymphoid/Immuneactivated leukocyte
Lymphoid/Immunemacrophage
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • four tandem EGF-like domains
  • two of them with calcium-binding sites
  • a single RGD motif, including several potential N and O glycosylation sites, coupled to a seven-span transmembrane segment (7TM) by a mucin-like spacer domain (site-specific N-glycosylation is an important determinant of (GPCR) proteolytic site proteolysis)
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Cd97
    homolog to rattus Rn.7386
    homolog to C.elegans F09A5.2
    Homologene
    FAMILY
  • G-protein coupled receptor 2 family
  • secretin-receptor superfamily
  • EGF-TM7 family of class II seven-span transmembrane (7-TM) molecules
  • CATEGORY adhesion , antigen , receptor membrane G
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • acting as a receptor potentially involved in both adhesion and signaling processes early after leucocyte activation
  • shows different features of expression and function in muscle cells compared to hematopoetic and tumor cells
  • is induced in multiple epithelial cancer lineages
  • plays an important role in tumor aggressiveness by binding its cellular ligand CD55
  • CD97 and CD55 both play important roles in tumor dedifferentiation, migration, invasiveness, and metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • CD97 heterodimerized and functionally synergized with LPAR1, a GPCR implicated in cancer progression
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • binding to CD95, decay accelerating factor (DAF,CD55)
  • CD97 functioned to mediate invasion in prostate cancer cells, at least in part, by associating with lysophosphatidic acid receptor 1 (LPAR1)
  • CD97, present on peripheral myeloid cells, is a novel interacting partner for THY1 (is an interacting partner for CD97 on activated endothelial cells)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastrointestinal carcinomas
    tumoral     --over  
    in primary gallbladder carcinoma
    constitutional     --over  
    on polymorphonuclear cells (PMNC) of patients with psoriasis
    tumoral     --over  
    of CD97 and its ligand CD55 at the invasion front correlate with rectal tumor recurrence and metastasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    potential therapeutic cancer target
    ANIMAL & CELL MODELS