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FLASH GENE

Symbol

AQP10

contributors: mct/npt/pgu - updated : 25-08-2012

HGNC name	aquaporin 10
HGNC id	16029

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine jejunum   specific Homo sapiens   intestine small intestine duodenum   specific Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial absorptive excretory digestive epithelium (mucosa)     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Digestive enterocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	cytosolic N-terminus
	six membrane-spanning domain
	three N-linked glycosylation sequons
	N-glycosylation signals
	a C-loop that is the longest of the human aquaporins

HOMOLOGY

interspecies

homolog to AQP9

intraspecies

homolog to AQP3,AQP9

Homologene

FAMILY	aquaglyceroporin family
	MIP/aquaporin family

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION	plasma membrane
text	localized on the apical compartment of the intestinal epithelium called the glycocalyx
	located in the apical membrane of enterocytes and is believed to contribute to the passage of water and glycerol through these intestinal absorptive cells

basic FUNCTION	aquaglyceroporins, that transport glycerol
	and small solutes in addition to water
	may be contribute to water transport in the upper portion of small intestine
	involvement of a carrier-mediated mechanism in glycerol transport by AQP10
	uniquely dual functional characteristic of AQP10 as a carrier/channel for solute transport
	transmembrane facilitator of both water and glycerol transport in the small intestine

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS