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FLASH GENE
Symbol ADAM18 contributors: npt/ - updated : 17-09-2004
HGNC name ADAM metallopeptidase domain 18
HGNC id 196
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion sperm
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one EGF-like domain
  • one disintegrin domain
  • a putative integrin-binding glu-cys-asp (ECD) motif
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase family M12B
  • ADAM (a disintegrin and metalloprotease domain) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • sperm surface membrane protein that may be involved in spermatogenesis and fertilization
  • playing a potential role in oocyte recognition
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS