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FLASH GENE
Symbol DTX2 contributors: mct/npt - updated : 09/12/2008
HGNC name deltex homolog 2 (Drosophila)
HGNC id 15973
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus   highly
Digestivemouth   predominantly
Endocrinepancreas   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal domain rich in glycine and arginine residues
  • a central domain containing RNP consensus sequence
  • a WWE domain, globular domain in several proteins and mediating specific protein-protein interactions in ubiquitin and ADP ribose conjugation systems
  • a RING domain, zinc-finger motif with 40-60 AAs binding to two zinc atoms, which is also probably involved in mediating protein-protein interactions
  • HOMOLOGY
    interspecies homolog to Drosophila Deltex 2
    Homologene
    FAMILY
  • deltex family
  • fibrillarin family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • RNA methyltransferase involved in the first step in processsing of preribosomal RNA
  • function as E3 ligases based on its capacity for self-ubiquitination (Takeyama 2003)
  • involved in the assembly and metabolism of SnoRNPs in the SMN complex
  • has an important role in pre-rRNA processing during ribosomal biogenesis
  • would play a critical role in the maintenance of nuclear shape and cellular growth
  • WWE-RING-finger protein and involved in regulating heart development and heart functions
  • can act as a negative regulator of Notch signals in T cells but that endogenous levels of DTX1 and DTX2 are not important for regulating Notch signals during thymocyte development
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding to U3, U8, U13 snRNAs
    small molecule
    protein
  • associated with several proteins, including PRMT1, tubulin alpha 3, and tubulin beta 1 to form a sub-complex that is principally independent of the association of FIB with preribosomal ribonucleoprotein complexes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS