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FLASH GENE
Symbol FAM3C contributors: SGE/npt - updated : 10-09-2009
HGNC name family with sequence similarity 3, member C
HGNC id 18664
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinesmall intestine  lowly
 liver   highly
Endocrinepancreas   highly
Lymphoid/Immunespleen   lowly
Nervousbrain   highly
Reproductivefemale systemplacenta  highly
 female systemovary  lowly
 male systemtestis  lowly
 male systemprostate  lowly
Respiratorylung   moderately
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal moderately
cells
SystemCellPubmedSpeciesStageRna symbol
Skeletonosteoblast
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a GG domain
  • a hydrophobic leader sequence
  • an N-terminal signal peptide
  • 4-helix bundle
  • HOMOLOGY
    interspecies ortholog to fam3c, Danio rerio
    ortholog to Fam3c, Mus musculus
    ortholog to Fam3c, Rattus norvegicus
    homolog to LOC463680, Pan troglodytes
    intraspecies homolog to FAM3A
    Homologene
    FAMILY
  • FAM3 family
  • CATEGORY secretory , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • FAM3C is a tumor- and metastasis-inducing protein cooperates with oncogenic Ras to cause and maintain TGF-b-independent epithelial to mesenchymal transition (EMT) of hepatocyte (Lahsnig et al 2009)
  • collaboration of FAM3C with oncogenic Ras enhances tumor formation, nuclear accumulation of b-catenin and Stat3 tyrosine phosphorylation (Lahsnig et al 2009)
  • play a role in the EMT regulation
  • may be involved in retinal laminar formation processes (Katahira 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cooperates with oncogenic Ras
  • ILEI stimulates upregulation of PDGF-C/PDGF-Rb and enhances proliferation and migration in oncogenic Ras-expressing MIM-R-GFP hepatocytes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS