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FLASH GENE
Symbol PDP1 contributors: mct/npt - updated : 14-03-2018
HGNC name pyruvate dehyrogenase phosphatase catalytic subunit 1
HGNC id 9279
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland    
Nervousbrain   highly
Skin/Tegumentskin    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PWWP (proline-tryptophan-tryptophan-proline) domain, involved in histone methylation regulation, that adopts a classical PWWP fold, with a five-strand antiparallel beta-barrel followed by three alpha-helices
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Pdp1
    homolog to murine LOC381511
    Homologene
    FAMILY
  • protein phosphatase 2C family of protein serine/threonine phosphatases (PP2C family)
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • dephosphorylating and reactivating the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC)
  • is a mitochondrial serine phosphatase that activates phosphorylated pyruvate dehydrogenase complex by dephosphorylation
  • mitochondrial PDP1 is a potential regulator that controls cardiac differentiation at an early differentiation stage in embryonic stem cells (ESCs)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text transit peptide
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer of a catalytic subunit and a FAD protein of unknown function
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Mg2+ dependent
  • Ca2+
  • protein
  • lipid-induced antagonism of CRAT might contribute to decreased PDP1 activity and glucose disposal in the context of obesity and diabetes
  • cell & other
    REGULATION
    activated by calcium Ca2+
    Other phosphorylation at different tyrosine residues inhibits likely PDP1 through independent mechanisms, which act in concert to regulate pyruvate dehydrogenase complex (PDC) activity and promote the Warburg effect
    ASSOCIATED DISORDERS
    corresponding disease(s) PDP1D
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    reduced activity of PDP in congenital chronic lactic acidosis
    constitutional     --other  
    PDP1 phosphorylation was increased in lymphocytes from the umbilical cord blood of the Gestational diabetes mellitus (GDM)patients and in high glucose-treated hepatic cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS