Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LXN contributors: mct - updated : 28-03-2009
HGNC name latexin
HGNC id 13347
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 mouthtongue   
Endocrineparathyroid   highly
Nervousbrain   moderately
Reproductivemale systemprostate  highly
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Nervouscentral   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N- and C-terminal domains
  • an alpha helix enveloped by a curved beta sheet, separated by a connecting segment
  • potential heparin/heparan sulfate-binding sites
  • two nearly identical domains that have a high conformational homology with the cystatins (Kadouchi 2009)
  • HOMOLOGY
    interspecies homolog to rattus carboxypeptidase A inhibitor
    intraspecies homolog to cystatins
    Homologene
    FAMILY protease inhibitor I47 (latexin) family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text nuclear localization of latexin in chondrocytes appearing during fracture repair (Kadouchi 2009)
    basic FUNCTION
  • specific inhibitor of carboxypeptidase A
  • metallocarboxypeptidases containing a characteristic alpha/beta hydrolase fold
  • plays an important role in regulating the activity of hematopoietic stem cells (Kadouchi 2009)
  • regulator of hematopoietic stem cells
  • involved in BMP2-induced chondrocyte differentiation and plays an important role in skeletogenesis and skeletal regeneration (Kadouchi 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component CPA4/LXN complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein interaction between latexin and heparan sulfate during extracellular matrix synthesis in cartilage (Kadouchi 2009)
    cell & other
    REGULATION
    induced by BMP2 in RUNX2-deficient mesenchymal cells during chondrocyte and osteoblast differentiation (Kadouchi 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the early phase of bone fracture (Kadouchi 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS