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FLASH GENE
Symbol CDCA2 contributors: npt/mct - updated : 24-09-2015
HGNC name cell division cycle associated 2
HGNC id 14623
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • PPP1CA binding domain
  • HOMOLOGY
    interspecies homolog to Drosophila CG13890
    homolog to C.elegans R06F6.9
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • forms an essential complex with PPP1CA gamma and is required for the recruitment of PPP1CA to chromatin
  • controls a protein phosphatase 1-dependent threshold for DNA damage checkpoint activation
  • is a key factor that coordinates chromatin remodeling and early events of nuclear envelope reformation during mitotic exit
  • might be associated closely with oral squamous cell carcinoma (OSCC) progression by preventing cell-cycle arrest and apoptosis
  • is a targeting subunit for the protein phosphatase 1 involved in the dephosphorylation of histone H3 during mitotic exit
  • is also essential for proper nuclear envelope reformation and the regulation of DNA damage responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complex CDCA2/PPP1CA inactivating mitotic chromosome structure during anaphase
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PPP1CA binding protein, which selectively recruits PPP1CAgamma onto mitotic chromatin at anaphase and into the following interphase
  • co-operating with condensin in the regulation of chromosome architecture during mitosis
  • two PP1-targeting subunits, PPP1R7 and CDCA2, counteracted AURKB-dependent phosphorylation of the outer kinetochore component DSN1 during anaphase
  • recruits protein phosphatase 1 to chromatin to antagonize activation of ataxia telangiectasia mutated (ATM)-dependent signal transduction
  • CDCA2-associated PP1 and PP2A collaborate to oppose the chromosomal targeting of AURKB
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    up-regulated in oral squamous cell carcinoma (OSCC) cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a very strong prognostic marker for poor patient survival in cancer
  • Therapy target
    ANIMAL & CELL MODELS