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FLASH GENE
Symbol BCAR3 contributors: mct - updated : 22-06-2016
HGNC name breast cancer anti-estrogen resistance 3
HGNC id 973
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   moderately
 mouthtongue  moderately
Endocrinethyroid   highly
Lymphoid/Immunelymph node   highly
Reproductivefemale systembreastmammary gland moderately
 female systemplacenta  highly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective   moderately
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative SRC homology 2 (SH2) domain, interacting with Tyr789 of PTPRA, interaction required for PTPRA-BCAR3-PTPR1-SRC interaction and promotes the integrin-induced movement of BCAR3 and BCAR1 to focal adhesion-enriched fractions
  • a Ras-GEF domain, that binds to BCAR1
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Bcar3 (85.9 pc)
    homolog to murine Bcar3 (86.1 pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • regulating cell growth and apoptosis in hormone-sensitive cells
  • may act as an adaptor protein
  • coupling activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells
  • acting as a guanyl-nucleotide exchange factor
  • involved in reponse to drug
  • implicated in the regulation of cell morphology, adhesion and migration
  • regulating SRC activity in the endogenous setting of breast cancer cells (Schuh 2010)
  • regulating the interaction between BCAR1 and SRC, qualitatively and quantitatively (Schuh 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • small GTPase mediated signal transduction
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with BCAR1, NEDD9, PTK2 and PTPN1
  • is an activator of SRC and is a molecular linker of PTPRA and BCAR1 (
  • BCAR3 plays an important role in the signaling pathways of insulin leading to cell cycle progression and cytoskeleton reorganization, but not SLC2A4 translocation
  • cell & other
    REGULATION
    Other regulated by cellular adhesion to extracellular matrix proteins
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    confering anti-estrogen resistance in breast cancer cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS