SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,organelle,lysosome
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| intracellular,cytoplasm,cytosolic
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text
| localized in the mitochondria and inducing apoptosis through the mitochondrial pathway |
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accumulation of BBC3 in the cytosol may be important for the participation of this protein in apoptosis without the need for prior transcription |
basic FUNCTION
| play a role in mediating TP53-induced cell death through the cytochrome c/Apaf-1-dependent pathway ( |
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required for the apoptosis induced by overexpression of TP53, by hypoxia and DNA-damaging drugs |
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couples the nuclear and cytoplasmic proapoptotic functions of TP53 |
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BH3-only Bcl-2 family protein and an essential mediator of DNA damage-induced apoptosis |
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regulation of expression may play a role in the development of hepatocellular carcinoma |
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plays a role in H2O2-induced apoptosis in colorectal cancer cells |
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imposes a significant barrier to c-Myc-driven lymphomagenesis |
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is competent to trigger Bax activity by itself |
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contributing to hepatocyte lipoapoptosis |
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critical roles in the depletion of adult stem cells induced by constitutively active TP53 |
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essential for endoplasmic reticulum-stress-induced cell death ( |
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estrogen target gene that mediates the apoptotic response to tamoxifen in human breast cancer cells |
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is essential for apoptosis of mitogen-activated B cells and for the control of memory B-cell survival |
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has a major role in the T cell- dependent B-cell immune response, and is a major regulator of memory B lymphocyte survival |
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is the more potent apoptosis inducer, because it can bind with high affinity to all pro-survival BCL2 family members |
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PMAIP1 and, albeit to a lesser extent, BBC3 are essential for DNA damage induced TP63-mediated killing of primordial follicle oocytes |
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PMAIP1 and BBC3 are critical for DNA damage-induced, TP63-mediated oocyte apoptosis |
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BCL2L11 and BBC3 can directly activate the proapoptotic proteins BAX and BAK1 to permeabilize mitochondria, leading to caspase activation and apoptosis |
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BCL2L11 and BBC3 are the sentinels that interconnect kinase signaling networks and the mitochondrion-dependent apoptotic program, which offers therapeutic insights for designing novel cell death mechanism-based anticancer strategies |
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is pivotal for oligodendroglial cell death induced by different cell death stimuli and might play a role in oligodendroglial cell death in multiple sclerosis (MS) |
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BBC3 mediates ER stress-induced mucosal epithelial apoptosis through the mitochondrial apoptotic pathway in portal hypertensive gastropathy (PHG) |
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is a critical determinant of the number of germ cells during ovarian development |
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is a critical regulator of germ cell death that acts during the migratory phase of oogenesis or very soon after the arrival of germ cells in the gonad |
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is invovled in the apoptosis of cerebral astrocytes upon ischemia and reperfusion (I/R) injury |
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involvement of BBC3 in cold preservation/rewarming-mediated pancreatic islet injury, possibly through modulating HMGB1- and oxidative stress-mediated injury to islets |
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is a major regulator of apoptosis |
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involvement of PUMA in pericyte migration induced by methamphetamine 7) |