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FLASH GENE
Symbol NUF2 contributors: mct/npt - updated : 01/10/2008
HGNC name NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
HGNC id 14621
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
 salivary gland   highly
Hearing/Equilibriumear   moderately
Lymphoid/Immunethymus   moderately
Nervousbrain    
Reproductivemale systemprostate   
 male systemtestis  highly
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  moderately
Connectivebone   
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Cdca1 (79.2 pc)
homolog to murine Nuf2 (73.2 pc)
Homologene
FAMILY
  • NUF2 family
  • CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,centromere
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • localized to kinetochores from late prophase to anaphase
  • localized specifically to the outer plate of the kinetochore
  • basic FUNCTION
  • acting at the centromere to establish a connection with the spindle for proper chromosome segregation
  • required for the spindle checkpoint
  • kinetochore component conserved from yeast to humans, is essential for proper chromosome alignment and segregation during mitosis (Wei 2006)
  • required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore
  • having a necessary role for correct binding of spindle checkpoint proteins to kinetochore (act independent of each other in kinetochore assembly, but their combined activities are required for checkpoint signaling)
  • kinetochore component conserved from yeast to humans, is essential for proper chromosome alignment and segregation during mitosis (Wei 2006)
  • directly connects kinetochores to spindle microtubules (Wilson-Kubalek 2008)
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell cycle, checkpoint
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a conserved protein complex associated with the centromere
  • component of the essential kinetochore- associated NDC80 complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CENPH (for kinetochore assembly)
  • cell & other
    REGULATION
    Other can be phosphorylated by AURKA and AURKB
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in lung cancer
    tumoral     --over  
    in colorectal and gastric cancers (Kaneko 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target suppression of NUF2 or NDC80 activity and/or inhibition of the NUF2-NDC80 complex formation could be a promising therapeutic target for treatment of lung cancers
    ANIMAL & CELL MODELS