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FLASH GENE
Symbol PIGU contributors: mct - updated : 11-09-2019
HGNC name phosphatidylinositol glycan anchor biosynthesis, class U
HGNC id 15791
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
Endocrinepancreas    
Nervousbrain    
 nerve   highly
 nervecranial nerve  highly
Reproductivemale systemprostate   
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
nine putative transmembrane domains
HOMOLOGY
interspecies homolog to yeast S.cerevisiae Cdc91
homolog to Drosophila CG13090
homolog to C.elegans F42G8.6
Homologene
FAMILY PIGU family
CATEGORY protooncogene
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
basic FUNCTION
  • may function in cell division control
  • may be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI
  • fifth component of GPI transamidase that may be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI
  • plays a role in the development of bladder urothelial cell carcinoma
  • might be involved in cell cycle-related biological processes in hepatocellular carcinoma (HCC)
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with PIGK/GPI8, PIGS, PIGT and GPAA1/GAA1
  • critical subunit of the glycosylphosphatidylinositol transamidase (GPI-T) complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PIGT, PIGU, and GPAA1 may form a core complex associated by PIGS, and these four subunits may stabilize PIGK, triggering GPI anchoring reactions
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GPIBD20
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    and amplified in bladder cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • overexpressed PIGU was an independent predictor for poor survival in hepatocellular carcinoma (HCC) patients
  • might be a potential biomarker for prediction of recurrence in bladder cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerurinary 
    therapeutic target in bladder cancer
    ANIMAL & CELL MODELS