basic FUNCTION
| involved in maintaining the transcriptionally repressive state of genes, modifies chromatin, rendering it heritably changed in its expressibility |
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repressor of proto-oncogenes |
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negative regulation of homeotic gene (Polycomb group) |
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functioning as a SUMO E3 ligase for DNMT3A and it might be involved in the functional regulation of DNA methyltransferases by promoting their SUMO modification |
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functions as a transcriptional suppressor, and is a candidate of FHL1-binding proteins |
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having ability to recruit both CTBP1 and UBE2I to polycomb group bodies |
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acting as a transcriptional co-repressor ( |
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maintains human epidermal stem cells as slow-cycling and undifferentiated, while protecting them from senescence |
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inhibits stem cell activation and differentiation through its SUMO ligase activity |
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has an essential and non-redundant role in thymic organogenesis |
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is a crucial regulator for the generation and maintenance of the thymic epithelium and, hence, for thymocyte development |