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FLASH GENE
Symbol CATSPER2 contributors: mct - updated : 22-03-2019
HGNC name cation channel, sperm associated 2
HGNC id 18810
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousnerve   predominantly
Reproductivemale systemtestis  specific
 male systemprostate  highly
Visualeye   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text highly in umbilical cord
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Ca2+ ion selective pore domain
  • a cellular localization
  • six transmembrane segments
  • HOMOLOGY
    interspecies homolog to murine Catsper2 (67.7pc)
    Homologene
    FAMILY
    CATEGORY regulatory , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text localized in sperm flagellum
    basic FUNCTION
  • involved in sperm cell motility
  • expressed during the meiotic or postmeiotic stages of spermatogenesis
  • having required roles in male fertility
  • CATSPER channel complex serves as a polymodal sensor for multiple chemical cues that assist sperm during their voyage across the female genital tract
  • CATSPER1, CATSPER2 are voltage-dependent calcium channels located in the plasma membrane of the sperm flagellum and is responsible for triggering hyperactive motility
  • CELLULAR PROCESS cell cycle,division,meiosis
    cell migration & motility
    PHYSIOLOGICAL PROCESS reproduction/sex
    text
  • cation transport (voltage-gated ion channel)
  • spermatogenesis
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • molecular mechanism responsible for activation of CATSPER1, CATSPER2 by progesterone arises early in sperm development concurrently with the CATSPER channel itself
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DIS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    in asthenoteratozoospermia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Catsper2 -/- mice