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FLASH GENE
Symbol CABYR contributors: - updated : 16-12-2006
HGNC name calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)
HGNC id 15569
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Reproductivemale systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatid
Reproductivespermatozoa
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a motif homologous to the RII dimerization domain of PK.A in the N terminus
  • a single putative EF handlike motif
  • eleven potential tyrosine phosphorylation-like sites
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY binding protein CBP86 family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text localized to the principal piece of the sperm flagellum in association with the fibrous sheath
    basic FUNCTION
  • may function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction, in spermatozoa
  • may play a role during brain development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , reproduction/sex
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+ (when phosphorylated during capacitation)
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrant expression in brain tumors and cancer cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS