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FLASH GENE
Symbol POLD4 contributors: mct/npt - updated : 23-06-2015
HGNC name polymerase (DNA-directed), delta 4
HGNC id 14106
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrinepancreas   moderately
 parathyroid   moderately
Lymphoid/Immunetonsils   predominantly
Reproductivefemale systemovary  moderately
 male systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion highly in lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated Other
mono polymer heteromer , tetramer
HOMOLOGY
interspecies ortholog to S. pombe Cdm1
homolog to rattus Pold4 (82.2 pc)
homolog to murine Pold4 (82.2 pc)
Homologene
FAMILY
  • DNA polymerase delta subunit 4 family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • required for optimal DNA polymerase delta activity
  • may contribute to PCNA-dependent activity of DNA polymerase delta
  • could play a role in stabilizing the overall pol delta-PCNA complex as well as pol delta itself
  • having functions in cell proliferation and maintenance of genomic stability of human cells (Huang 2010)
  • required for maintaining the proper nuclear structures suggesting that the pathological structures reflect elevated DNA damage in chromosomes (Huang 2010)
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, replication
    nucleotide, repair, nucleotide excision repair
    PHYSIOLOGICAL PROCESS
    text positive regulation of endothelial cell proliferation
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of DNA polymerase delta
  • heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa
  • ubiquitinated
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with WRNIP1
  • binds to POLD1, POLD2, and an accessory protein of PCNA, which allows pol delta to exhibit its full activity (Huang 2010)
  • interacting with BLM
  • RNF8 participates in the regulation of POLD4
  • cell & other
    REGULATION
    Other rapid degradation, regulated by ATR, occurred in response to UV or genotoxic treatment of HeLa and HEK293T cells
    degraded in response to DNA damage through the ubiquitin-proteasome pathway
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    is associated with impaired AKT1-SKP2-p27 pathway in lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS