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FLASH GENE
Symbol LANCL2 contributors: mct - updated : 23-02-2013
HGNC name LanC lantibiotic synthetase component C-like 2 (bacterial)
HGNC id 6509
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   moderately
 salivary gland   highly
Lymphoid/Immunethymus   highly
Nervousbrain   highly
 nervecranial nerve  highly
Reproductivefemale systemuteruscervix highly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • unique N-terminus that function as the membrane anchor with a relevant N-terminal myristoylation and a basic phosphatidylinositol phosphate-binding site
  • a unique ATP/GTP-binding site motif A (P-loop)
  • HOMOLOGY
    interspecies homolog to rattus Lancl2 (88.6 pc)
    homolog to murine Lancl2 (89.5 pc)
    intraspecies homolog to LANCL1
    Homologene
    FAMILY
  • eukaryotic LanC-like protein family
  • lanthionine synthetase component C-like (LANCL) protein family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • major localization to the plasma membrane, juxta-nuclear vesicles, and the nucleus
  • basic FUNCTION
  • involved in the negative regulation of transcription
  • increasing cellular sensitivity to Adriamycin by decreasing the expression of P-gp
  • its overexpression enhances the cellular sensitivity to the anticancer drug adriamycin and this sensitivity is dependent on the myristoylation and membrane association of LANCL2
  • critical component of the abscisic acid (ABA) -sensing protein complex will enable the screening of synthetic ABA antagonists as prospective new anti-inflammatory and anti-diabetic agents
  • required for ABA binding to the plasma membrane of granulocytes and for the activation of the signaling pathway triggered by ABA in human granulocytes
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of a peptide-modifying complex
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • binding to ATP
  • binding to GTP
  • protein
    cell & other
    REGULATION
    activated by ABA, abscisic acid (ABA activates the human protein LANCL2 via direct bindin)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification --over  
    being a bystander gene coamplified and overexpressed with epidermal growth factor receptor (EGFR) in approximately 20 pc of all glioblastomas
    constitutional     --over  
    interacts with the cortical actin cytoskeleton and therefore may play a role in cytoskeleton reorganization and in consequence to cell detachment
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS