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FLASH GENE
Symbol RHOJ contributors: mct - updated : 10-01-2017
HGNC name ras homolog gene family, member J
HGNC id 688
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
 vessel   predominantly
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated LipoP , Other
mono polymer monomer
HOMOLOGY
interspecies homolog to Drosophila cg8500
homolog to C.elegans c54a12.4
ortholog to murine Rhoj
ortholog to rattus rhoj_predicted
intraspecies homolog to TC10
homolog to CDC42
Homologene
FAMILY
  • small GTPase superfamily
  • Rho family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • GTPase playing a role in the actin filament organization
  • involved in insulin-stimulated glucose transport
  • GIT1, GIT2, ARHGEF7 and RHOJ all colocalised in focal adhesions and depended on each other for their recruitment to focal adhesions
  • molecular function of RHOJ in regulating cell motility and tumour vessel formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP
    protein binding to CDC42/Rac interacting binding domain of PAK or WASP
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • RhoJ-knockout mice showed reduced tumour growth and diminished tumour vessel density, identifying a role for RhoJ in mediating tumour angiogenesis