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FLASH GENE
Symbol AGFG2 contributors: np/ - updated : 13-11-2007
HGNC name ArfGAP with FG repeats 2
HGNC id 5177
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   moderately
Hearing/Equilibriumear   highly
Lymphoid/Immunespleen   highly
Nervousbrain    
 nerve   highly
Reproductivefemale systemovary  moderately
 female systemplacenta  moderately
Visualeye   moderately
cell lineage
cell lines
fluid/secretion moderately in blood and lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an Arf-GAP C4-type zinc finger domain
  • several phe-gly (FG) motifs (characteristic of nucleoporin-like proteins)
  • four asn-pro-phe (NPF) motifs located in the C terminal half
  • HOMOLOGY
    interspecies homolog to Drosophila drongo
    homolog to rattus Hrbl (84 pc)
    homolog to murine Hrbl (83.2 pc)
    Homologene
    FAMILY
  • HIV-1 Rev binding protein (HRB) family
  • CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in the regulation of GTPase
  • playing a role in the Rev export pathway, which mediates the nucleocytoplasmic transfer of proteins and RNAs
  • playing a role as cellular cofactor of the human immunodeficiency virus Rev protein (pathogenic invasion)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • binding to EH domain of EPS15
  • interacting with EPS15R
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS