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FLASH GENE
Symbol PTBP2 contributors: mct/pgu - updated : 20-03-2020
HGNC name polypyrimidine tract binding protein 2
HGNC id 17662
EXPRESSION
Rna function
  • mRNA transcripts are found in neuronal precursor cells and other nonneuronal cells, but in these cells PTBP2 protein expression is repressed
  • Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrain   highly
     nerve   predominantly Homo sapiens
    Reproductivemale systemtestis  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    four RNA recognition motifs (RRM)
    conjugated sumoylated
    HOMOLOGY
    interspecies ortholog to murine Ptbp2
    homolog to Drosophila CG8831
    intraspecies homolog to PTB
    homolog to SNRP70
    Homologene
    FAMILY PTB (polypyrimidine tract-binding )protein family
    CATEGORY regulatory , RNA associated , antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • in the spliceosome
  • is a nucleocytoplasmic shuttle protein
  • basic FUNCTION
  • involved in controling the assembly of other splicing-regulatory proteins
  • enhancing the binding of two other proteins (hnRNPH and KSRP) to the DCS RNA
  • possible retinal autoantigen of cancer-associated retinopathy (CAR)
  • potential trans-acting factor that helps to stabilize PGK2 mRNA in male germ cells
  • post-transcriptional switch from PTBP1 to PTBP2 controls a widespread alternative splicing program during neuronal development
  • promoting pre-mRNA 3' end processing in collaboration with hnRNPH
  • PTBP1, a splicing regulator, is replaced in the brain and differentiated neuronal cell lines by PTBP2
  • potential role for PTBP2 in neurogenesis
  • PTBP1 and its brainspecific homologue, PTBP2, are associated with pre-mRNAs and influence pre-mRNA processing, as well as mRNA metabolism and transport
  • controls a genetic program essential for neuronal maturation
  • PTBP2 is required for alternative splicing regulation in the testis, as in brain
  • functions as a key regulator of alternative pre-mRNA splicing in the nucleoplasm and promotes internal ribosome entry site-mediated translation initiation of viral and cellular mRNAs in the cytoplasm
  • PTBP1 and PTBP2, are also nonconserved cryptic exon repressors and PTBP1 and PTBP2, are also nonconserved cryptic exon repressors, and PTBP1 and PTBP2 are members of a family of cryptic exon repressors
  • PTBP1 and PTBP2 reprogram developmental pre-mRNA splicing in neurons
  • PTBP1 and PTBP2 serve both specific and redundant functions in neuronal pre-mRNA splicing
  • PTBP2 controls a network of genes involved in cell adhesion, migration, and polarity, suggesting that splicing regulation by PTBP2 is critical for germ cell communication with Sertoli cells
  • is a key alternative splicing regulator for male germ cell development
  • is an essential factor in heat stress-induced sperm cell injury and non-obstructive azoospermia
  • necessary and sufficient to convert non-neuronal cells to the neuronal lineage
  • is a new possible target for chronic myeloid leukemia (CML) and progressive inclusion/exclusion of PTBP2 exon 10 might play an important role in CML progression
  • PTBP2-orchestrated alternative splicing programming is required for robust generation of a single axon in mammals
  • PTBP1, PTBP2 are essential for B cell development
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    text differentiation of hematopoietic cells
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding to the intronic cluster of RNA regulatory elements, downstream control sequence (DCS)
  • binding to the HBB 3'UTR
  • small molecule
    protein
  • TP53 internal ribosome entry sites (IRES) interacting trans-acting factor (PTBP2 binds specifically to both the TP53 IRESs but with differential affinity)
  • CELF1 interacts with PTB proteins (PTBP1, PTBP2) (CELF1 and PTB proteins modulate the inclusion of TPM2 exon 6B during myogenic differentiation)
  • interacts with AICDA (PTBP2 is thus an effector of class-switch recombination that promotes the binding of AICDA to switch-region DNA)
  • re-expression of PTBP1 or PTBP2 in differentiated neurons inhibited DLG4 expression and impaired the development of glutamatergic synapses
  • cell & other
    REGULATION
    Other PTBP2 is posttranslationally modified by SUMO1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS