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FLASH GENE
Symbol SSBP3 contributors: mct/np - updated : 27-04-2017
HGNC name single stranded DNA binding protein 3
HGNC id 15674
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinelarge intestinecolon highly
Nervousnervecranial nerve  highly
Reproductivemale systemprostate  highly
Respiratoryrespiratory tractlarynx  highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a well-preserved FWD (FORWARD)-domain at the N-terminal end
  • a LISH domain
  • a proline-, glycine-, methionine- and serine-rich sequence in the central and C-terminal regions, possessing an entire transcription activity
  • HOMOLOGY
    interspecies homolog to murine Prp3
    ortholog to chicken Csdp
    Homologene
    FAMILY SSBP family
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • essential cofactor in the transcription regulation of embryonic development
  • acting in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex
  • BTBD9, CRLF3, and SSBP3 regulate likely neuronal morphology and the biogenesis/transport of synaptic vesicles
  • SSBP3 is a critical component of LDB1-ISL1 regulatory complexes, required for expression of critical beta-cell target genes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with LDB1 (cofactor of LDB1) to regulate development
  • SSBP3 inhibits LHX2 and LDB1 turnover, stimulates assembly of this DNA-binding complex, promotes its recruitment to the CGA promoter, and enhances CGA transcription
  • SSBP3 interacts with LDB1 and ISL1 in beta-cell lines and in human islets and is coexpressed with LDB1 and ISL1 pancreas tissue
  • SSBP2, SSBP3 control LMO4 and LDB1 protein abundance in a cancer context
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS