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FLASH GENE
Symbol GRIP1 contributors: mct/npt - updated : 22-02-2016
HGNC name glutamate receptor interacting protein 1
HGNC id 18708
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrineneuroendocrinepituitary  highly
 parathyroid   highly
Nervousbrainbasal nuclei  moderately
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven PDZ domain at the C-terminus (required for interaction between FRAS1 and GRIP1)
  • kinesin binding domain
  • HOMOLOGY
    interspecies C.elegans KO7H8.3
    Homologene
    FAMILY
    CATEGORY signaling neurotransmitter , transport
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • enabling kinesis to transport dendritic proteins such as AMPA receptor subunit GLUR2
  • required for cell-matrix interactions during early embryonic development
  • may play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons
  • playing an important role in dendrite morphogenesis by serving as an adaptor protein for kinesin-dependent transport of EPHB receptors to dendrites
  • binds to and regulates both the trafficking and membrane organization of a large number of transmembrane proteins (Long 2008)
  • previously unidentified role for AMPA-R-GRIP1-exocyst protein complexes in activity-dependent AMPA-R trafficking
  • may serve to organize macromolecular complexes, linking AMPA-Rs and other membrane proteins to the cytoskeleton and membrane trafficking and signal transduction pathways
  • multi-PDZ domain-containing protein that interact with the C-termini of AMPA-R GRIA2 and GRIA3 subunits
  • regulatory role for GRIP1 during microtubule-based transport and suggest a crucial function for 14-3-3 proteins in controlling kinesin-1 motor attachment during neuronal development
  • essential role of GRIP1-mediated AMPAR trafficking during inactivity-induced synaptic scaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
  • GLUR2/GRIP1 complex
  • ephrin B1 EFNB1/GRIP1 complex
  • kinesin/GRIP1 complex
  • homomultimers or heteromultimers with GRIP2
  • forms a ternary complex with GRIA2 and CSPG4
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EFNB1 and EFNB3
  • kinesin
  • GLUR2
  • DIP2(coactivation of transcription)
  • required for the deposition of both FRAS1 and FREM2 on the basement membrane, possibly through interactions with the cytoplasmic tails of these proteins
  • interacting with SUV420H1 (GRIP1-associated “secondary” cofactor for GR (glucocorticoid receptor), and active modulator of hormone-dependent gene expression) (Chinenov 2008)
  • interacting with FRAS1 (provides a mechanistic explanation of the link between GRIP1 and the Fraser syndrome but may also serve as a foundation for searching for potential mutations in GRIP1 that could lead to the Fraser syndrome) (Long 2008)
  • bind to the C-termini of AMPA-R GRIA2 and GRIA3 subunits
  • CREB1 mediates the PRKAA-stimulated degradation of GRIP1 through protein-protein interaction and stimulation of proteasomal degradation of ubiquitinated GRIP1
  • TRIP6-GRIP1-MYO6 interaction and its regulation on F-actin network play a significant role in dendritic morphogenesis
  • activity-dependent trafficking of GRIP1 to synaptic sites drives the forward trafficking and enhanced synaptic accumulation of GRIA2-containing AMPAR during synaptic scaling up
  • cell & other
    REGULATION
    Other regulated by cAMP-dependent protein kinase (PKA) that induces its degradation through the ubiquitin-proteasome pathway
    ASSOCIATED DISORDERS
    corresponding disease(s) FRAS3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    in Fraser syndrome
    constitutional germinal mutation      
    in isolated Congenital anomalies of the kidney and urinary tract (CAKUT)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    deleted in the eye-blebs (eb) of mouse