SUBCELLULAR LOCALIZATION
| plasma membrane,junction
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytosolic,vesicle
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basic FUNCTION
| enabling kinesis to transport dendritic proteins such as AMPA receptor subunit GLUR2 |
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required for cell-matrix interactions during early embryonic development |
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may play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons |
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playing an important role in dendrite morphogenesis by serving as an adaptor protein for kinesin-dependent transport of EPHB receptors to dendrites |
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binds to and regulates both the trafficking and membrane organization of a large number of transmembrane proteins (Long 2008) |
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previously unidentified role for AMPA-R-GRIP1-exocyst protein complexes in activity-dependent AMPA-R trafficking |
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may serve to organize macromolecular complexes, linking AMPA-Rs and other membrane proteins to the cytoskeleton and membrane trafficking and signal transduction pathways |
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multi-PDZ domain-containing protein that interact with the C-termini of AMPA-R GRIA2 and GRIA3 subunits |
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regulatory role for GRIP1 during microtubule-based transport and suggest a crucial function for 14-3-3 proteins in controlling kinesin-1 motor attachment during neuronal development |
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essential role of GRIP1-mediated AMPAR trafficking during inactivity-induced synaptic scaling |
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