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FLASH GENE
Symbol ADRM1 contributors: mct/npt - updated : 10-10-2018
HGNC name adhesion regulating molecule 1
HGNC id 15759
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   highly
Lymphoid/Immunespleen   highly
Nervousbrain   highly
Respiratorylung   moderately
Skin/Tegumentskin   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectiveadipose  moderately
Connectivebone   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extracellular domain rich in serine and threonine residues
  • a conserved N-terminal region termed the pleckstrin-like receptor for ubiquitin domain (Pru)
  • a DEUBAD domain in ADRM1 activating UCHL5
  • a C-terminal half binding directly to the proteasome-associated deubiquitinating enzyme, UCHL5, and enhancing its isopeptidase activity, and containing KEKE motifs
  • C-terminal region of ADRM1 binds to the tetratricopeptide repeat (TPR) domain of SGTA, a cytosolic factor implicated in the quality control of mislocalised membrane proteins (MLPs)
  • conjugated GlycoP , Other
    mono polymer heteromer , complex
    isoforms Precursor heavily glycosylated, which increased the mass of the 42-kDa peptide to 110 kDa
    HOMOLOGY
    interspecies homolog to rattus Adrm1 (96.6 pc)
    homolog to murine Adrm1 (96.6 pc)
    Homologene
    FAMILY
  • GP110 family
  • ADRM1 family
  • CATEGORY adhesion , regulatory , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • promoting cell adhesion
  • playing an important role for the binding of UCHL5 to the 19S complex and for efficient proteolysis
  • recruiting UCHL5, a deubiquitinating enzyme known to associate with 26 proteasomes
  • having a specialised role in proteasome function
  • acting as an activator of proteasome
  • acting as a ubiquitin receptor in the proteasome
  • recruits UCHL5, a deubiquitinating enzyme known to associate with 26 proteasomes (Hamazaki 2006)
  • essential for the activity of UCHL5 (Hamazaki 2006)
  • required for cell migration and osteoclast maturation (Kim 2009)
  • proteasome subunit that functions as novel ubiquitin receptor (Kim 2009)
  • a new ATP6V0D2-interacting protein, playing an important role in osteoclast differentiation, and in particular the fusion of preosteoclasts (Kim 2009)
  • is an intrinsic ubiquitin receptor of the 26S proteasome regulatory subunit that facilitates substrate capture prior to degradation
  • ADMR1 and PSMD4 function as ubiquitin receptors of the proteasome
  • ADRM1 mostly plays a redundant role with PSMD4 in recognition of ubiquitinated proteins and maintaining likely homeostasis
  • ADMR1 and UCHL5 are implicated in cell cycle progression, providing a rationale for their function in cellular proliferation
  • role of ADMR1 as a proteasomal ubiquitin receptor
  • CELLULAR PROCESS nucleotide, transcription, elongation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS immunity/defense
    text
  • tumor antigen
  • RNA elongation from RNA polymerase II promoter
  • PATHWAY
    metabolism
    signaling
    a component
  • component of the regulatory ATPase complex of the 26 S proteasome
  • INTERACTION
    DNA
    RNA
    small molecule other,
  • ubiquitin
  • protein
  • binding C-terminal tail domain of UCHL5, and relieved the autoinhibition
  • proteasome interacting protein
  • interaction between ATP6V0D2 and ADRM1 (Kim 2009)
  • interacting with UCHL5 (Nishio 2009)
  • phosphorylated TP63 induces transcription of ADRM1, leading to NOS2 protein degradation
  • UCHL5 is a de-ubiquitinating enzyme that is activated by ADRM1 and involved in the proteasomal degradation of proteins
  • interaction of PSMD1 with ADRM1 is controlled by SUMOylation in a manner that may alter proteasome composition and function
  • ADMR1 can activate UCHL5 by disrupting dimerization, although physiologically relevant activation likely results from stabilization of a surface competent for ubiquitin binding and modulation of the active-site crossover loop
  • binding of SGTA to ADRM1 enables specific polypeptides to escape proteasomal degradation and/or selectively modulates substrate degradation
  • ADRM1 plays an important role in mediating removal of mutant Htt aggregates when excess HAPF8A140 is present
  • direct interaction between SGTA and the proteasome, mediated by the intrinsic proteasomal ubiquitin receptor ADRM1 (27827410)
  • is recruited to the proteasome through direct interaction with the large scaffolding protein PSMD1 within the 19S regulatory particle
  • binds ubiquitin with an affinity similar to that of other proteasome-associated ubiquitin receptors
  • PSMD1, ubiquitin, and the deubiquitylase UCHL5 bind to ADRM1 with independent energetics
  • F8A1 -mediated reduction of ADRM1 alters the mitochondrial fission activity and results in mitochondrial fragmentation and mitochondrial dysfunction
  • cell & other
    REGULATION
    induced by interferon gamma
    Other acetylated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    expression induced by gamma-interferon in gastric carcinoma
    tumoral     --over  
    in high grade serous carcinoma (HGSC) of the ovary and serous tubal intraepithelial carcinoma (STIC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    novel therapeutic target for ovarian cancer
    ANIMAL & CELL MODELS