Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol C1D contributors: mct - updated : 23-08-2013
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nuclear localization signal (NLS)
  • HOMOLOGY
    interspecies homolog to murine Suncor
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • exosome-associated protein and thus might regulate its functional activities
  • playing a role with MPP6 and SKIV2L2 in the recruitment of the exosome to pre-rRNA to mediate the 3' end processing of the 5.8S rRNA
  • activator of the DNA-dependent protein kinase (DNA-PK), which is essential for the repair of DNA double-strand breaks (DSBs) and V(D)J recombination
  • associated with DNA repair complex and may promote repair of UV-induced DNA damage
  • is essential for wild-type ciliary beating
  • role for C1D in coordinating the activity of specific dynein isoforms to control ciliary motility
  • C1D projection is involved in the control of interdoublet sliding velocity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complex associated with the C1D projection of the central apparatus that PCDP1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TRAX (may be to regulate TRAX/Translin complex formation)
  • C1D facilitates ERCC3 DNA repair through direct interaction with ERCC3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene major autoantigen in patients with the PM-scleroderma overlap syndrome and suggest that the use of recombinant as an autoantibody target may aid in diagnosis of the PM-scleroderma overlap syndrome
    Marker
    Therapy target
    ANIMAL & CELL MODELS