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FLASH GENE
Symbol PDGFD contributors: - updated : 13-08-2007
HGNC name platelet derived growth factor D
HGNC id 30620
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   moderately
 vesselsaorta  moderately
Endocrineadrenal gland   highly
 neuroendocrinepituitary  moderately
Reproductivefemale systemuterus  moderately
 male systemtestis  moderately
Respiratoryrespiratory tracttrachea  predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective   moderately
cell lineage
cell lines adrenal cortex carcinoma
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 23 amino acids signal peptide (2.6 kDa)
  • N terminal CUB domain
  • C terminal PDGF cystine knot growth factor domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to chimpanzee PDGFD (100.00 pc)
    homolog to murine Pdgfd (85.14 pc)
    homolog to chicken PDGFD (81.15 pc)
    Homologene
    FAMILY
  • PDGF/VEGF growth factor superfamily
  • CATEGORY enzyme , signaling growth factor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION protease important for growth survival and fucntion in several types of connective tissue cells
    CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein PDGFR-beta, specifically
    cell & other
    REGULATION
    activated by limited proteolysis
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS